Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor.
نویسندگان
چکیده
Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, optically modulated delivery of nanoprobes into the tumor parenchyma with minimal off-target distribution.
منابع مشابه
Size-Controlled Synthesis of Gold Nanostars and Their Characterizations and Plasmon Resonances
Gold nanostar particles were synthesized using seed-mediated method. Au-seed was synthesized with the diameter of approximately 3 nm and a considerably low STDEV of less than 1 nm. Then, different amount of Au seed was introduced into the growth solution of nanostars and the influence of the changes in concentration of Au seed on the growth process was investigated. The size of gold nanostars i...
متن کاملDevelopment of nanostars as a biocompatible tumor contrast agent: toward in vivo SERS imaging
The need for sensitive imaging techniques to detect tumor cells is an important issue in cancer diagnosis and therapy. Surface-enhanced Raman scattering (SERS), realized by chemisorption of compounds suitable for Raman spectroscopy onto gold nanoparticles, is a new method for detecting a tumor. As a proof of concept, we studied the use of biocompatible gold nanostars as sensitive SERS contrast ...
متن کاملMultifunctional gold nanostars for molecular imaging and cancer therapy
Plasmonics-active gold nanoparticles offer excellent potential in molecular imaging and cancer therapy. Among them, gold nanostars (AuNS) exhibit cross-platform flexibility as multimodal contrast agents for macroscopic X-ray computer tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), as well as nanoprobes for photoacoustic tomography (PAT), two-photon photolu...
متن کاملNear‐infrared light‐sensitive liposomes for enhanced plasmid DNA transfection
Near-infrared (NIR) light-responsive liposomes are attractive carriers for targeted and controlled drug delivery to the superficial organ or tissue (e.g., skin). This work describes the development of NIR-responsive liposomes by incorporating gold nanostars within liposomes composed of Phospholipon 90 g and cholesterol. Following cellular delivery, photothermal effect around the gold nanostar u...
متن کاملDosimetric Effects of Rotational Setup Error in Volumetric Modulated Arc Radiotherapy on Brain Tumor Patients
Introduction: This study examined the dosimetric effects based on the rotational setup error to correct patient setup errors occur during volumetric modulated arc radiotherapy (VMAT) for brain tumor patients. Material and Methods: This study included 1129 cases of cone beam computed tomography (CBCT) images obtained from 46 brain tumor patients, who experienced VMAT and used the 6DoF (degree o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Nanoscale
دوره 6 8 شماره
صفحات -
تاریخ انتشار 2014